Disabling a bov is very very bad for a turbo.
The TB is closed, not allowing the pressurised gas to go anywhere.... the turbo is still spooling, but now there is a massive positive pressure on the outlet, causing a huge resistance on the compressor wheel. This increases the stress on all the components of the turbo, increasing temperature, increasing wear etc.
In the old days cars didnt have bov's... but they werent expected to last long.
Expect problems to develop quick with that.